tecovirimat will increase the stage or influence of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Keep track of. Tecovirimat is a weak inhibitor of CYP2C8 and CYP2C19. Keep track of for adverse consequences if coadministered with sensitive substrates of these enzymes.
ethinylestradiol will improve the level or impact of diazepam by Mechanism: lowering metabolism. Use Caution/Keep track of. Ethinyl estradiol may perhaps inhibit the clearance of benzodiazepines that undergo oxidation, thus expanding serum concentrations of concomitantly administered benzodiazepines.
Are allergic to diazepam. Have a watch dilemma named acute slender-angle glaucoma. What need to I tell my medical doctor prior to taking VALTOCO?
This info should not be interpreted with no aid of a Health care provider. If you think that you are experiencing an conversation, Call a Health care provider immediately. The absence of the conversation isn't going to essentially suggest no interactions exist.
diazepam will raise the amount or effect of tinidazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
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Concomitant usage of benzodiazepines, which include diazepam, and opioids might result in profound sedation, respiratory depression, coma, and Demise; reserve concomitant prescribing of benzodiazepines and opioids to be used in patients for whom alternative procedure alternatives are insufficient; lessen opiate dose a single-3rd when diazepam is included
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diazepam will improve the stage or influence of lonafarnib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. If coadministration of lonafarnib (a sensitive CYP3A substrate) with weak CYP3A inhibitors is unavoidable, cut down to, or keep on lonafarnib at starting dose.
There have already been postmarketing stories of coma and Demise with coadministration of buprenorphine and benzodiazepines. In lots of, although not most of these instances, buprenorphine was misused by self-injection. If a benzodiazepine needs to be useful for a sign aside from seizures, lessen the benzodiazepine First dose and cautiously titrate to clinical response.
artemether/lumefantrine will lessen the extent or impact of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
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